Attaran Saina, Punjabi Prakash P, Anderson Jon
Cardiothoracic Department, Hammersmith Hospital, Imperial College, London, UK.
J Atr Fibrillation. 2012 Oct 6;5(3):671. doi: 10.4022/jafib.671. eCollection 2012 Oct-Nov.
Post cardiac surgery atrial fibrillation is common after cardiac surgery. Despite the advances in medical and surgical treatment, its incidence remains high and unchanged for decades. The aim of this review was to summarize studies published in 2011 on identifying factors, prevention strategies, treatment and effect of post operative atrial fibrillation (POAF) on the outcome after cardiac surgery. A review was performed on Medline, Embase and Chocrane on all of the English-language, peer-reviewed published clinical studies on POAF; studies investigating the mechanism of developing POAF, prevention, treatment and outcome were all included and analyzed. Case reports, studies on persistent/preoperative atrial fibrillation (AF), POAF after cardiac transplant, congenital cases and nonclinical studies were all excluded. We have also valuated these studies based on the type of the study, their originality, impact factor of the journal and their limitations. Overall 62 studies were reviewed and analyzed; 26 on POAF predictive factors, 31 on preventative strategies and 6 on the outcome of POAF. Of these studies only two were original and the remaining were either performed in AF in general population (n=10) or had been studied and reported several times before in cardiac surgery (n=50). The average impact factor of the journals that POAF was published in was only 2.8 ranging between 0.5 and 14.5. Post cardiac surgery atrial fibrillation is a multi-factorial and complex condition. Cardiac surgery may be a risk factor for developing POAF in patients already susceptible to this condition and may not be a complication of cardiac surgery. Future studies should mainly focus on histological changes in the conductive tissue of atrium and related treatment strategies rather than predictive factors of POAF and more funding should be made available to study this condition from new and entirely different perspectives.
心脏手术后房颤在心脏手术后很常见。尽管在药物和手术治疗方面取得了进展,但其发病率几十年来一直居高不下且没有变化。本综述的目的是总结2011年发表的关于识别心脏手术后房颤(POAF)的因素、预防策略、治疗以及POAF对心脏手术后结局影响的研究。对Medline、Embase和Cochrane数据库进行了检索,纳入所有关于POAF的英文、经同行评审发表的临床研究;纳入并分析了研究POAF发生机制、预防、治疗及结局的研究。病例报告、关于持续性/术前房颤(AF)的研究、心脏移植术后的POAF、先天性病例及非临床研究均被排除。我们还根据研究类型、原创性、期刊影响因子及其局限性对这些研究进行了评估。总共对62项研究进行了综述和分析;26项关于POAF预测因素,31项关于预防策略,6项关于POAF结局。在这些研究中,只有两项是原创性的,其余的要么是在一般人群的房颤中进行的(n = 10),要么是之前在心脏手术中已经研究和报道过多次的(n = 50)。发表POAF相关研究的期刊平均影响因子仅为2.8,范围在0.5至14.5之间。心脏手术后房颤是一种多因素且复杂的病症。心脏手术可能是已易患此病的患者发生POAF的危险因素,而不一定是心脏手术的并发症。未来的研究应主要关注心房传导组织的组织学变化及相关治疗策略,而非POAF预测因素,并应提供更多资金从全新且截然不同的角度研究此病。