Department of Forensic Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
J Sep Sci. 2011 Apr;34(8):901-24. doi: 10.1002/jssc.201000795. Epub 2011 Mar 11.
Monolith was first used as a material for chromatographic separation two decades ago and solid-phase extraction over 10 years, and since then, separation science has undergone a dramatic change owing to advancements in analytical technology. Recently, monolith has been modified to suit various devices for the extraction and enrichment of analytes in any matrices of environmental, food, and biological analyses. This approach has contributed to miniaturization and automation for sample preparation, and it can reduce the time and cost requirements of sample preparation. Recently, numerous applications have been demonstrated for online and inline preconcentration coupled with monolith, and many kinds of devices have been designed and developed for offline devices. In this review, these applications and devices are listed and discussed in reference to other fields.
二十年前，整体材料首次被用于色谱分离，十年前用于固相萃取，自此，分析技术的进步使分离科学发生了巨大变化。最近，整体材料经过改良，适用于各种装置，用于提取和浓缩环境、食品和生物分析中各种基质中的分析物。这种方法有助于样品制备的小型化和自动化，可减少样品制备的时间和成本要求。最近，已经有许多关于与整体材料在线和在线预浓缩相结合的应用得到了证明，并且已经设计和开发了许多用于离线设备的装置。在这篇综述中，列出并讨论了这些应用和装置，并与其他领域进行了比较。
