Hara Hitoshi, Ishii Eri, Hondo Tomomi, Nakagawa Miki, Teramoto Katsuhiro, Oyama Toshio
Pathology Division, Yamanashi Prefectural Central Hospital, Yamanashi, Japan.
Diagn Cytopathol. 2012 Aug;40(8):724-8. doi: 10.1002/dc.21657.
Neuroendocrine tumors of the uterine cervix (UC) are rare, and atypical carcinoid (AC) combined with adenocarcinoma of the uterine cervix (ACAUC) is particularly rare. Only the histopathology has been investigated in the English literature. A 49-year-old female with a polypoid lesion of the UC visited Yamanashi Prefectural Central Hospital. Scraping cytology, biopsy, and hysterectomy was performed. EC smears showed solid, rosette, honeycomb,true tubular, and trabecular clusters. Solid clusters were oval, thin-edge, delicate, small-large nuclei, pale, granular, scant, nothing,and well-preserved (though ill-defined border) cytoplasm. Rosette clusters were eccentric, oval nuclei, mixture of coarsely granular chromatin and euchromatin, and cyanophilic luminal content. Solid and rosette clusters impress AC. Honeycomb clusters involved a clearly defined border and translucent mucin. True tubular clusters were oval nuclei of fine chromatin or euchromatin, thick cytoplasm,and orange luminal content. Honeycomb and true tubular clusters suspected adenocarcinoma. Trabecular clusters were fusiform, columnar, cuboidal, and polygonal cell shapes of small,monotonous nuclei, and contained coarsely granular chromatin with occasionally intracytoplasmic translucent mucin and were difficult to differentiate typical carcinoid and adenocarcinoma.Histology was AC combined with adenocarcinoma. The aim of this study was to investigate the cytological characteristics of ACAUC.
子宫颈神经内分泌肿瘤（UC）较为罕见，非典型类癌（AC）合并子宫颈腺癌（ACAUC）则尤为罕见。英文文献中仅对其组织病理学进行过研究。一名患有UC息肉样病变的49岁女性就诊于山梨县中央医院。进行了刮片细胞学检查、活检及子宫切除术。EC涂片显示有实性、菊形团、蜂窝状、真性管状和小梁状细胞团。实性细胞团呈椭圆形，边缘薄，质地细腻，细胞核大小不一，淡染，颗粒状，稀少，无内容物，细胞质保存良好（尽管边界不清）。菊形团细胞团细胞核偏心，呈椭圆形，染色质粗糙颗粒状与常染色质混合，管腔内容物嗜蓝。实性和菊形团细胞团提示为AC。蜂窝状细胞团边界清晰，有半透明黏液。真性管状细胞团细胞核呈椭圆形，染色质细腻或为常染色质，细胞质厚，管腔内容物呈橙色。蜂窝状和真性管状细胞团提示腺癌。小梁状细胞团细胞呈梭形、柱状、立方状和多边形，细胞核小且单一，含有粗糙颗粒状染色质，偶尔有胞质内半透明黏液，难以区分典型类癌和腺癌。组织学检查为AC合并腺癌。本研究的目的是探讨ACAUC的细胞学特征。
