Tannenbaum J, Hulman S, Falkner B
Department of Pediatrics, Hahnemann University, Philadelphia, Pennsylvania 19102.
Am J Perinatol. 1990 Apr;7(2):174-7. doi: 10.1055/s-2007-999474.
To test the hypothesis that atrial natriuretic peptide (ANP) concentration in the newborn is negatively related to plasma renin concentration (PRC), as it is in the adult, we measured the concentration of both substances in the same plasma sample. We studied 24 well term newborns and 20 samples of umbilical venous blood from normal deliveries. Both ANP and PRC are elevated in newborn plasma, but not in umbilical venous plasma. ANP levels on the second day of life are greater than either day 1 or day 3. Linear regression of ANP and PRC demonstrates a highly significant negative correlation [r = -0.65, p less than 0.001], which suggests that the suppression of the renin-angiotensin system by ANP seen in the adult may be intact in the newborn. ANP may act to blunt the effects of the augmented renin-angiotensin system of the newborn and promote normal neonatal diuresis.
为了验证新生儿心房利钠肽（ANP）浓度与血浆肾素浓度（PRC）呈负相关这一假说（如同在成年人中那样），我们在同一血浆样本中测量了这两种物质的浓度。我们研究了24名足月健康新生儿以及20份正常分娩的脐静脉血样本。新生儿血浆中的ANP和PRC均升高，但脐静脉血浆中则不然。出生后第二天的ANP水平高于第一天或第三天。ANP与PRC的线性回归显示出高度显著的负相关[r = -0.65，p < 0.001]，这表明在成年人中观察到的ANP对肾素 - 血管紧张素系统的抑制作用在新生儿中可能是完整的。ANP可能起到减弱新生儿增强的肾素 - 血管紧张素系统的作用，并促进正常的新生儿利尿。
