Department of Psychiatry, Columbia University, New York, NY 10032, USA.
Eur J Neurosci. 2011 Mar;33(6):1152-9. doi: 10.1111/j.1460-9568.2011.07614.x.
The neurogenesis hypothesis of depression was originally formed upon the demonstration that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work has established that newborn neurons in the dentate gyrus are required for mediating some of the beneficial effects of antidepressant treatment. Recent studies combining behavioral, molecular and electrophysiological approaches have attempted to make sense of the role young neurons play in modulating mood by demonstrating a potential role in regulating the circuitry in the brain that underlies depression. Here we discuss the work that led to the neurogenesis hypothesis of depression, and the subsequent studies that have sought to test this hypothesis. We also discuss different animal models of depression that have been used to test the role of neurogenesis in mediating the antidepressant response.
抑郁症的神经发生假说最初是在证明应激会影响海马体中的成年神经发生水平时形成的。从那时起，大量的工作已经证实，齿状回中的新生神经元对于介导抗抑郁治疗的一些有益效果是必需的。最近的研究结合行为、分子和电生理学方法，试图通过证明其在调节抑郁相关大脑回路中的作用，来理解年轻神经元在调节情绪中的作用。在这里，我们讨论了导致抑郁症神经发生假说的工作，以及随后为了验证该假说而进行的研究。我们还讨论了用于测试神经发生在介导抗抑郁反应中的作用的不同抑郁症动物模型。
