Department of Communication Sciences and Disorders, College of Behavioral and Community Sciences, University of South Florida, Tampa, FL, USA.
J Eval Clin Pract. 2012 Jun;18(3):689-94. doi: 10.1111/j.1365-2753.2011.01650.x. Epub 2011 Mar 13.
RATIONALE, AIMS AND OBJECTIVES: Recovery of language function in individuals with post-stroke aphasia is associated with a variety of patient and stroke-related indices. Amidst a complex interaction of a multitude of variables, clinicians are faced with the arduous challenge of predicting aphasia recovery patterns and subsequently, long-term outcomes in these individuals. Unfortunately, predictive factors are highly variable making prognosis of aphasia recovery difficult. Therefore, the objective of this review was to assess the influence of patient-related and stroke-related factors on language recovery in individuals with post-stroke aphasia.
We completed a literature review to assess and identify evidence-based patient and stroke-related variables shown to be influential in aphasia recovery.
A range of patient-related (gender, handedness, age, education, socio-economic status and intelligence) and stroke-related indices (initial severity, lesion site and lesion size) were identified as potential influential factors to post-stroke aphasia recovery. Initial severity of aphasia emerged as the factor most predictive of long-term aphasia recovery. Other influential factors of post-stroke language recovery included lesion site and size.
Stroke-related factors, including aphasia severity, lesion site and lesion size, appear most critical to post-stroke aphasia recovery. The findings presented in this review offer clinicians an evidenced-based framework to assist in prediction of post-stroke aphasia recovery patterns and subsequent long-term functional communication outcomes.
背景、目的和目标：脑卒中后失语症患者的语言功能恢复与多种患者和卒中相关指标有关。在众多变量的复杂相互作用中，临床医生面临着艰巨的挑战，即预测失语症恢复模式，并随后预测这些患者的长期结局。不幸的是，预测因素高度可变，使得失语症恢复的预后变得困难。因此，本综述的目的是评估与患者相关和与卒中相关的因素对脑卒中后失语症患者语言恢复的影响。
我们完成了文献综述，以评估和确定已证明对失语症恢复有影响的基于证据的患者和卒中相关变量。
一系列与患者相关的因素（性别、利手性、年龄、教育、社会经济地位和智力）和与卒中相关的指标（初始严重程度、病灶部位和病灶大小）被确定为可能影响卒中后失语症恢复的因素。失语症的初始严重程度是预测长期失语症恢复的最具预测性的因素。卒中后语言恢复的其他影响因素包括病灶部位和大小。
与卒中相关的因素，包括失语症严重程度、病灶部位和病灶大小，对卒中后失语症恢复最为关键。本综述中的研究结果为临床医生提供了一个基于证据的框架，以帮助预测卒中后失语症恢复模式和随后的长期功能交流结局。
