基于韩国第三次全国健康与营养检查调查数据的韩国老年人代谢综合征与估算肾小球滤过率之间的关联
Association between metabolic syndrome and estimated glomerular filtration rate in older Koreans based on data from the third Korean National Health and Nutrition Examination Survey.
作者信息
Park Yong Soon, Kim Jun-Su
机构信息
Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Australas J Ageing. 2011 Mar;30(1):16-21. doi: 10.1111/j.1741-6612.2010.00440.x.
AIM
To examine the association between metabolic syndrome (MetS) and renal function in older Koreans.
METHODS
A total of 1270 people aged 60 years and older who participated in the third Korean National Health and Nutrition Examination Survey were included in this study.
RESULTS
After adjusting for confounding factors, central obesity, high-density lipoprotein cholesterol and fasting glucose were significantly associated with decreased renal function in men. In women, however, each component of MetS with the exception of fasting glucose was not associated with renal function. The odds ratios for MetS were 2.548 in men and 1.454 in women after adjustment for confounding variables; both were statistically significant. The odds ratio of decreased renal function increased as the number of components of MetS increased.
CONCLUSION
The results of this study suggest that MetS may be an independent risk factor for decreased renal function in older population as well.
目的
研究韩国老年人代谢综合征（MetS）与肾功能之间的关联。
方法
本研究纳入了1270名60岁及以上参与第三次韩国全国健康与营养检查调查的人群。
结果
在对混杂因素进行调整后，男性的中心性肥胖、高密度脂蛋白胆固醇和空腹血糖与肾功能下降显著相关。然而，在女性中，除空腹血糖外，MetS的各组分与肾功能均无关联。在对混杂变量进行调整后，男性MetS的优势比为2.548，女性为1.454；两者均具有统计学意义。肾功能下降的优势比随着MetS组分数量的增加而升高。
结论
本研究结果表明，MetS可能也是老年人群肾功能下降的一个独立危险因素。
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