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Comparative cellular biogerontology: primer and prospectus.比较细胞生物老年学：入门与展望。
Ageing Res Rev. 2011 Apr;10(2):181-90. doi: 10.1016/j.arr.2010.01.002. Epub 2010 Jan 28.
2
Age-related auditory pathology in the CBA/J mouse.CBA/J小鼠中与年龄相关的听觉病理学
Hear Res. 2008 Sep;243(1-2):87-94. doi: 10.1016/j.heares.2008.06.001. Epub 2008 Jun 7.
3
Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone.来自长寿物种的皮肤成纤维细胞对某些（但并非全部）致死性应激以及线粒体抑制剂鱼藤酮具有抗性。
Aging Cell. 2007 Feb;6(1):1-13. doi: 10.1111/j.1474-9726.2006.00255.x. Epub 2006 Dec 5.
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Oxidative imbalance in the aging inner ear.衰老内耳中的氧化失衡。
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Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.来自长寿突变品系成年小鼠的成纤维细胞系对多种应激形式具有抗性。
Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E23-9. doi: 10.1152/ajpendo.00575.2004. Epub 2005 Feb 8.
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Multiplex stress resistance in cells from long-lived dwarf mice.长寿矮小小鼠细胞中的多重抗逆性。
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Positive correlation between mammalian life span and cellular resistance to stress.哺乳动物寿命与细胞应激抗性之间的正相关。
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Hypothesis: interventions that increase the response to stress offer the potential for effective life prolongation and increased health.假设：增强对应激反应的干预措施具有有效延长寿命和增进健康的潜力。
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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.单基因突变赋予并由热应激诱导的热耐受性和延长的寿命。
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皮肤成纤维细胞对过氧化物和紫外线损伤的抵抗力预测衰老小鼠的听力损失。

Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.

机构信息

Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.

出版信息

Aging Cell. 2011 Apr;10(2):362-3. doi: 10.1111/j.1474-9726.2010.00668.x. Epub 2011 Feb 1.

DOI:10.1111/j.1474-9726.2010.00668.x
PMID:21395967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3079202/
Abstract

Those mice whose skin-derived primary fibroblast cell lines resist lethal injury induced by hydrogen peroxide or UV light show lower age-related decline in hearing. Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice.

摘要

那些皮肤来源的原代成纤维细胞系能够抵抗过氧化氢或紫外线诱导的致死性损伤的老鼠，其听力随年龄增长而下降的程度较低。皮肤细胞系可能提供了一种易于获得的内在应激抵抗的替代指标，这种抵抗在个体之间存在差异，并影响衰老老鼠神经感觉下降的速度。