皮肤成纤维细胞对过氧化物和紫外线损伤的抵抗力预测衰老小鼠的听力损失。
Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.
机构信息
Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.
出版信息
Aging Cell. 2011 Apr;10(2):362-3. doi: 10.1111/j.1474-9726.2010.00668.x. Epub 2011 Feb 1.
Abstract
Those mice whose skin-derived primary fibroblast cell lines resist lethal injury induced by hydrogen peroxide or UV light show lower age-related decline in hearing. Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice.
摘要
那些皮肤来源的原代成纤维细胞系能够抵抗过氧化氢或紫外线诱导的致死性损伤的老鼠，其听力随年龄增长而下降的程度较低。皮肤细胞系可能提供了一种易于获得的内在应激抵抗的替代指标，这种抵抗在个体之间存在差异，并影响衰老老鼠神经感觉下降的速度。
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