比较细胞生物老年学：入门与展望。
Comparative cellular biogerontology: primer and prospectus.
机构信息
Department of Pathology, University of Michigan Medical School, Ann Arbor, 48109, United States.
出版信息
Ageing Res Rev. 2011 Apr;10(2):181-90. doi: 10.1016/j.arr.2010.01.002. Epub 2010 Jan 28.
Most prior work on the biological basis of aging has focused on describing differences between young and old individuals but provided only limited insight into the mechanisms controlling the rate of aging. Natural selection has produced a goldmine of experimental material, in the form of species of differing aging rate, whose longevity can vary by 10-fold or more within mammalian orders, but these resources remain largely unexplored at the cellular level. In this review article we focus on one approach to comparative biogerontology: the strategy of evaluating the properties of cultured cells from organisms of varying lifespan and aging rate. In addition, we discuss problems associated with the analysis and interpretations of interspecific variation of cellular trait data among species with disparate longevity. Given the impressive array of 'natural experiments' in aging rate, overcoming the technical and conceptual obstacles confronting research in comparative cellular gerontology will be well worth the effort.
大多数关于衰老生物学基础的先前研究都集中在描述年轻个体和老年个体之间的差异，但仅对控制衰老速度的机制提供了有限的深入了解。自然选择产生了大量的实验材料，以不同衰老速度的物种形式存在，其寿命在哺乳动物目中可以相差 10 倍甚至更多，但这些资源在细胞水平上在很大程度上仍未得到探索。在这篇综述文章中，我们专注于比较生物老年学的一种方法：评估来自不同寿命和衰老速度的生物体的培养细胞的特性的策略。此外，我们还讨论了在具有不同寿命的物种之间分析和解释细胞特征数据的种间变异性所涉及的问题。鉴于衰老速度的“自然实验”令人印象深刻，克服比较细胞老年学研究面临的技术和概念障碍将是非常值得的。
Zotero 插件