Department of Reproductive, Developmental and Public Health Sciences, UCO Hygiene and Preventive Medicine, University of Trieste, Italy.
Epidemiol Infect. 2011 Nov;139(11):1727-33. doi: 10.1017/S095026881100032X. Epub 2011 Mar 14.
Two distinct measles outbreaks, unrelated from the epidemiological point of view but caused by genetically related strains, occurred in the Friuli Venezia Giulia region of northeastern Italy. Forty-two cases were reported during the period April-May 2008. In the first outbreak the index case was a teacher who introduced the virus into the Pordenone area, involving eight adolescents and young adults. The other concomitant outbreak occurred in the city of Trieste with 33 cases. The containment of the epidemics can be explained by the high MMR vaccine coverage in an area where the first dose was delivered to 93·4% and the second dose to 88·3% of the target children. Phylogenetic analysis of 14 measles virus strains showed that they belonged to a unique D4 genotype indistinguishable from the MVs/Enfield.GBR/14.07 strain, probably introduced from areas (i.e. Piedmont and Germany) where this genotype was present or had recently caused a large epidemic.
意大利东北部弗留利-威尼斯朱利亚地区发生了两起截然不同的麻疹疫情，从流行病学角度来看，这两起疫情并无关联，但却是由基因相关的病毒株引起的。2008 年 4 月至 5 月期间报告了 42 例病例。在第一起疫情中，一名教师将病毒带入了波德诺内地区，导致 8 名青少年和年轻人感染。另一起疫情同时发生在的里雅斯特市，有 33 例病例。在该地区，MMR 疫苗的高覆盖率可以解释疫情的控制情况，目标儿童中有 93.4%接种了第一剂疫苗，88.3%接种了第二剂疫苗。对 14 株麻疹病毒株的系统进化分析表明，它们属于独特的 D4 基因型，与 MVs/Enfield.GBR/14.07 株无法区分，该病毒株可能是从存在该基因型或最近引发大规模疫情的地区（如皮埃蒙特和德国）传入的。
