Frau Nicola, Meloni Federico, Fostinelli Jacopo, Portas Laura, Portoghese Igor, Sala Emma, Pilia Ilaria, Lecca Luigi Isaia, De Palma Giuseppe, Campagna Marcello
Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria di Monserrato, SS 554 bivio per Sestu, Monserrato, 09042 Cagliari, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy.
Vaccines (Basel). 2021 Oct 16;9(10):1191. doi: 10.3390/vaccines9101191.
Determining the proportion of susceptible workers can represent a first step to the biological risk assessment related to measles, mumps, rubella and varicella exposure. This study aimed to assess the immunity against measles, mumps, rubella and varicella viruses in a cohort of female school workers.
A cross-sectional seroepidemiological study in a sample of 263 school workers undergoing routine annual workplace health surveillance program was conducted. As part of the health surveillance program, serum samples were collected and tested for measles, mumps, rubella and varicella IgG antibodies.
Overall seropositivity was 90.5%, 85.2%, 94.7% and 97.3% for measles, mumps, rubella and varicella, respectively. In relation to mumps occupation-specific seropositivity, a statistically significant difference was observed, showing the lowest prevalence of protected individuals in other occupation groups. Moreover, in relation to rubella, school workers born in Centre Italy had the lowest seropositivity of protective antibodies and the difference between groups was statistically significant. Measles and rubella seropositivity showed a significant decrease after 2015.
This study showed a relevant proportion of school workers susceptible to the aforementioned diseases. These results highlighted the need for proper health surveillance and immunological controls in school workers, especially for females, and provided useful insights to policymakers to select effective strategies aimed at containing the risk of vaccine-preventable diseases at schools.
确定易感工人的比例是与麻疹、腮腺炎、风疹和水痘暴露相关的生物风险评估的第一步。本研究旨在评估一组女性学校工作人员对麻疹、腮腺炎、风疹和水痘病毒的免疫力。
对263名接受年度常规工作场所健康监测计划的学校工作人员进行了横断面血清流行病学研究。作为健康监测计划的一部分，采集血清样本并检测麻疹、腮腺炎、风疹和水痘IgG抗体。
麻疹、腮腺炎、风疹和水痘的总体血清阳性率分别为90.5%、85.2%、94.7%和97.3%。关于腮腺炎的职业特异性血清阳性率，观察到有统计学意义的差异，显示其他职业组中受保护个体的患病率最低。此外，关于风疹，出生在意大利中部的学校工作人员保护性抗体的血清阳性率最低，且组间差异有统计学意义。2015年后，麻疹和风疹的血清阳性率显著下降。
本研究表明相当比例的学校工作人员对上述疾病易感。这些结果强调了对学校工作人员，尤其是女性进行适当健康监测和免疫控制的必要性，并为政策制定者选择旨在控制学校疫苗可预防疾病风险的有效策略提供了有用的见解。
