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从肉苁蓉中提取的糖链的分子特征和抗肿瘤能力。

Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum.

机构信息

Department of Medicine & Oncology, the Third Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Int J Biol Macromol. 2011 Jun 1;48(5):788-92. doi: 10.1016/j.ijbiomac.2011.03.001. Epub 2011 Mar 9.

DOI:10.1016/j.ijbiomac.2011.03.001
PMID:21396396
Abstract

Glycan were isolated from Cynomorium songaricum and flavone was extracted from Ginkgo leaf. This glycan was well fractionated into three fractions (CSG-F1, CSG-F1, and CSG-F3). The spectra were recorded at the absorbance mode from 4000 to 400 cm(-1) (mid infrared region) at the resolution of 8 cm(-1). The fourier transform infrared (IR) spectrum displayed a broad peak at 3438 cm(-1) and 2928 cm(-1) that corresponded to the stretching vibration of -OH group. The Ginkgo leaf flavone markedly inhibited the growth of human liver carcinoma cell line HepG2. However, C. songaricum glycan did not displayed strong antitumor activity.

摘要

从锁阳中分离出糖,并从银杏叶中提取黄酮。该糖被很好地分离成三个部分(CSG-F1、CSG-F2 和 CSG-F3)。在 4000 到 400 厘米(中红外区)之间以 8 厘米(1)的分辨率记录光谱。傅里叶变换红外(IR)光谱在 3438 厘米(1)和 2928 厘米(1)处显示出对应于-OH 基团的伸缩振动的宽峰。银杏叶黄酮明显抑制人肝癌细胞系 HepG2 的生长。然而,锁阳聚糖没有表现出很强的抗肿瘤活性。

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