Public Health Genomics, National Institute for Health and Welfare (THL), Biomedicum, Haartmaninkatu 8, Helsinki, Finland.
Best Pract Res Clin Endocrinol Metab. 2011 Feb;25(1):19-23. doi: 10.1016/j.beem.2010.10.013.
Human height is a very heritable trait as most of other human anthropometric traits. Genome-wide association studies have thus far identified about 200 genes associated with height with a genome-wide significance. Very large meta-analyses were needed to achieve this. These 200 height genes are involved in various biologically plausible pathways for growth, but yet explain only 10% of the variance in height. So it is obvious, that the GIANT-consortium height meta-analysis leaves, as most of GWA studies, a major part of the genetic variation unexplained. Much work utilizing several different strategies and very large study cohorts are needed to identify more genes for growth.
人类身高是一种非常具有遗传性的特征，与大多数其他人类人体测量特征一样。全基因组关联研究迄今为止已经确定了大约 200 个与身高相关的基因，这些基因具有全基因组意义。要做到这一点，需要进行非常大规模的荟萃分析。这些 200 个身高基因涉及到生长的各种生物学上合理的途径，但仅解释了身高变异的 10%。因此，很明显，正如大多数全基因组关联研究一样，GIANT 联盟身高荟萃分析仍然有很大一部分遗传变异未得到解释。需要利用多种不同策略和非常大规模的研究队列来识别更多与生长相关的基因。
