Department of Surgery, Second Hospital of HeBei Medical University, Shijiazhuang 050000, PR China.
Eur J Med Chem. 2011 May;46(5):1453-62. doi: 10.1016/j.ejmech.2011.01.021. Epub 2011 Jan 21.
We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.
我们描述了一类新型的β-咔啉生物碱-肽缀合物，它们具有自由基清除和溶栓活性。这些缀合物在大鼠动脉血栓形成试验中表现出治疗效果，并且在 PC12 细胞存活试验中评估具有自由基清除能力。我们的结果表明，β-咔啉生物碱-肽缀合物 26a 对大鼠肢体 I/R 损伤引起的局部和远处器官损伤具有显著的保护作用。
