新型β-咔啉三肽缀合物减轻大鼠肠系膜缺血/再灌注损伤。
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat.
机构信息
Department of Surgery, Second Hospital of HeBei Medical University, School of Basic Medical Sciences, HeBei Medical University, Shijiazhuang 050000, PR China.
出版信息
Eur J Med Chem. 2011 Jun;46(6):2441-52. doi: 10.1016/j.ejmech.2011.03.029. Epub 2011 Mar 21.
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that β-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.
我们合成了一系列新的β-咔啉-三肽缀合物，并在二甲苯诱导的小鼠耳肿胀模型中研究了它们的抗炎特性。这些化合物的镇痛能力在啮齿动物尾巴闪烁试验中进一步进行了评估。我们的研究结果表明，β-咔啉缀合物 4a 表现出强大的抗炎和镇痛活性，同时对大鼠肠系膜缺血/再灌注（I/R）损伤具有保护作用。
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