Head and Neck Oncology Tumour Stream, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.
Int J Oral Maxillofac Surg. 2011 Jul;40(7):710-4. doi: 10.1016/j.ijom.2011.02.010. Epub 2011 Mar 10.
Adenoid cystic carcinoma is a tumour of glandular cells responsible for 10% of salivary gland neoplasms. It has a high rate of perineural spread but limited involvement of regional lymphatics even in late stage disease. Early survival is typically good (60-90%) although long term survival is poor with spread to distant sites in 40-60% of cases. The authors performed a retrospective review of clinical and pathological records for 24 patients managed by their institution over a 22-year period. The overall 5, 10 and 20-year survival rates in this study were 92%, 72% and 54%, respectively. Perineural invasion was seen in 63% and close or positive margins seen in 64% of all primary resection specimens although survival was not associated with any clinical factor other than the initial size of lesion. Most patients presented complaining of a lump, whilst a burning neuralgia-type pain was the second most common symptom. The study confirms the conclusion of previous studies that tumour size at diagnosis is the most important predictor of outcome.
腺样囊性癌是一种由腺细胞组成的肿瘤，占唾液腺肿瘤的 10%。它具有较高的神经周围扩散率，但即使在晚期疾病中，区域淋巴结受累也有限。早期生存率通常较好（60-90%），尽管在 40-60%的病例中，肿瘤扩散到远处部位，长期生存率较差。作者对他们所在机构在 22 年期间治疗的 24 例患者的临床和病理记录进行了回顾性分析。在这项研究中，患者的总体 5 年、10 年和 20 年生存率分别为 92%、72%和 54%。63%的原发性切除标本中存在神经周围侵犯，64%的标本切缘接近或阳性，尽管除了病变的初始大小之外，生存率与任何临床因素均无关。大多数患者因肿块就诊，而第二种最常见的症状是灼烧神经痛样疼痛。该研究证实了以前研究的结论，即诊断时的肿瘤大小是预测结果的最重要因素。
