Copelli C, Bianchi B, Ferrari S, Ferri A, Sesenna E
Maxillo-Facial Surgery, Head and Neck Department, University of Parma, Via Gramsci 14, Parma (Pr), Italy.
Oral Oncol. 2008 Jul;44(7):658-63. doi: 10.1016/j.oraloncology.2007.08.018. Epub 2007 Nov 9.
Between 1995 and 2004, 43 patients with intraoral minor salivary gland carcinomas were diagnosed and treated at the Department of Maxillofacial Surgery, University of Parma, Italy. The palate was the most common site of involvement and comprised 53.5% of the cases. Adenoid cystic carcinoma was the most common histological type (60.6%), followed by mucoepidermoid carcinoma (27.9%). All patients were treated with surgery as the primary modality. Neck dissection was performed in 20.9% of patients, and more than half (72.1%) were treated with adjuvant radiation therapy. The range of the follow-up was 24-132 months (mean: 66 months). Of the 43 patients examined in this study, 12 died due to the tumor. Treatment failure was documented in 18 of the 43 patients (41.9%). Disease-free intervals ranged from 1 month to 9 years and 13.9% of the patients had local failure, whereas 25,6% had distant metastases. The survival rates at 2, 5, and 10 years were 90.7%, 71.8%, and 68%, respectively. The local control rates were 93.1% at 2 years and 83.1% at 5 and 10 years. The 2-, 5-, and 10-year rates for freedom from distant relapse were 95.2%, 83.4%, and 57.5%, respectively. The T stage, cervical lymph node metastasis, surgical margin status and perineural invasion were statistically significant to the outcome.
1995年至2004年间，意大利帕尔马大学颌面外科诊断并治疗了43例口腔内小涎腺癌患者。腭部是最常受累的部位，占病例的53.5%。腺样囊性癌是最常见的组织学类型（60.6%），其次是黏液表皮样癌（27.9%）。所有患者均以手术作为主要治疗方式。20.9%的患者进行了颈部清扫术，超过一半（72.1%）的患者接受了辅助放疗。随访时间为24 - 132个月（平均：66个月）。在本研究检查的43例患者中，12例死于肿瘤。43例患者中有18例（41.9%）记录有治疗失败。无病间期从1个月到9年不等，13.9%的患者有局部失败，而25.6%有远处转移。2年、5年和10年的生存率分别为90.7%、71.8%和68%。2年局部控制率为93.1%，5年和10年为83.1%。2年、5年和10年无远处复发率分别为95.2%、83.4%和57.5%。T分期、颈部淋巴结转移、手术切缘状态和神经周围侵犯对预后有统计学意义。
