Department of Psychology, Southwestern University, Georgetown, TX 78626, United States.
Pharmacol Biochem Behav. 2011 Jun;98(4):575-82. doi: 10.1016/j.pbb.2011.03.001. Epub 2011 Mar 21.
The present study evaluated the effects of methamphetamine (MA) on sexual behavior in female rats. In Experiment 1, ovariectomized, hormone-primed rats were injected with MA (1.0mg/kg, i.p.) or saline prior to a test for mate choice wherein females could mate with two males simultaneously. Female rats treated with saline returned to their preferred mate faster after receiving intromissions and visited their preferred mate at a higher rate than their non-preferred mate. In contrast, MA-treated female rats spent a similar amount of time with their preferred and non-preferred mate and failed to return to their preferred mate faster than to their non-preferred mate following intromissions. Two weeks later, the females received the same drug treatment but were tested for partner preference wherein females could spend time near a male or female stimulus rat. All subjects spent more time near the male stimulus than the female stimulus. However, the MA-treated rats visited the male stimulus more frequently and spent less time near the female stimulus than the saline-treated rats. Similar to Experiment 1, female rats in Experiment 2 were tested for mate choice and then two weeks later tested for partner preference; however, females received three daily injections of MA (1.0mg/kg, i.p.) or saline. Females treated chronically with MA returned to both males faster following intromissions than females treated with saline, independent of preference (i.e., preferred mate and non-preferred mate). Furthermore, MA-treated rats were more likely to leave either male (i.e., preferred or non-preferred mate) than saline-treated rats after receiving sexual stimulation. Although MA-treated subjects spent more time near the male stimulus than the female stimulus, they spent less time near either when compared to saline-treated subjects. The present results demonstrate that MA affects sexual behavior in female rats partly by increasing locomotion and partly by directly affecting sexual behavior.
本研究评估了甲基苯丙胺（MA）对雌性大鼠性行为的影响。在实验 1 中，去卵巢、激素预处理的大鼠在进行配偶选择测试前接受 MA（1.0mg/kg，ip）或生理盐水注射，在此测试中，雌性大鼠可以同时与两只雄性大鼠交配。接受生理盐水治疗的雌性大鼠在接受插入后更快地回到其首选伴侣身边，并且比非首选伴侣更快地访问其首选伴侣。相比之下，接受 MA 治疗的雌性大鼠与首选和非首选伴侣花费的时间相似，并且在接受插入后，它们没有比非首选伴侣更快地回到首选伴侣身边。两周后，雌性大鼠接受相同的药物治疗，但进行了伴侣偏好测试，在此测试中，雌性大鼠可以在雄性或雌性刺激大鼠附近花费时间。所有研究对象在雄性刺激大鼠附近花费的时间都多于在雌性刺激大鼠附近花费的时间。然而，与生理盐水处理的大鼠相比，MA 处理的大鼠更频繁地访问雄性刺激大鼠，并且在雌性刺激大鼠附近花费的时间更少。与实验 1 相似，实验 2 中的雌性大鼠先进行配偶选择测试，然后两周后进行伴侣偏好测试；然而，雌性大鼠接受了每日三次 MA（1.0mg/kg，ip）或生理盐水注射。与生理盐水处理的大鼠相比，接受慢性 MA 处理的大鼠在接受性刺激后更快地回到两只雄性大鼠身边，而与偏好无关（即首选雄性和非首选雄性）。此外，与生理盐水处理的大鼠相比，接受 MA 处理的大鼠在接受性刺激后更有可能离开任一只雄性（即首选或非首选雄性）。尽管 MA 处理的大鼠比生理盐水处理的大鼠更接近雄性刺激物，但与生理盐水处理的大鼠相比，它们更接近雌性刺激物。本研究结果表明，MA 通过增加运动和直接影响性行为，部分影响雌性大鼠的性行为。
