Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK.
Behav Brain Res. 2011 Aug 1;221(1):311-3. doi: 10.1016/j.bbr.2011.03.011. Epub 2011 Mar 10.
Antipsychotic drugs are widely used in the treatment of schizophrenia. While their effects are considered to be due to a modulation of dopaminergic and serotonergic signaling, little is known about their effects on noradrenergic (NA) activity in the brain. In this study, rats received either a 6d or 14 d treatment with haloperidol using osmotic minipumps. Noradrenaline responses to novelty, appetitive food and to an aversive tail pinch were measured in the prefrontal cortex, nucleus accumbens and caudate putamen (CPu) using in vivo microdialysis. Haloperidol significantly decreased baseline NA levels after short and long term treatment. A tail pinch significantly increased NA activity in the CPu. This effect was attenuated by haloperidol in a treatment duration-dependent way. This study suggests that haloperidol modulates NA baseline activity and reduces NA responses to mildly aversive stimuli depending on treatment duration.
抗精神病药物广泛用于治疗精神分裂症。虽然它们的作用被认为是通过调节多巴胺能和血清素能信号来实现的，但对于它们对大脑去甲肾上腺素（NA）活性的影响知之甚少。在这项研究中，大鼠通过渗透微型泵接受了 6 天或 14 天的氟哌啶醇治疗。使用活体微透析法在前额叶皮层、伏隔核和尾壳核（CPu）中测量了对新奇、食欲食物和厌恶尾部刺痛的去甲肾上腺素反应。氟哌啶醇在短期和长期治疗后显著降低了基线 NA 水平。尾部刺痛显著增加了 CPu 中的 NA 活性。这种效应在氟哌啶醇的治疗时间依赖性方式下被减弱。这项研究表明，氟哌啶醇调节 NA 的基础活动，并根据治疗时间减少对轻度厌恶刺激的 NA 反应。
