镍钛形状记忆合金和硅橡胶输卵管塞在兔体内的可逆避孕效果。

Reversible contraceptive effect of the oviduct plug with nickel-titanium shape memory alloy and silicone rubber in rabbits.

机构信息

Key Laboratory for Improving Birth Outcome Technique, Shandong Provincial Family Planning Institute of Science and Technology, Shandong 250002, China.

出版信息

Contraception. 2011 Apr;83(4):373-7. doi: 10.1016/j.contraception.2010.08.005.

DOI:10.1016/j.contraception.2010.08.005

PMID:21397098

Abstract

BACKGROUND

The aim of this study was to observe the contraceptive effectiveness and reversibility of the oviduct plug with nickel-titanium (Ni-Ti) shape memory alloy and silicone rubber in rabbits.

STUDY DESIGN

The oviduct plugs with Ni-Ti shape memory alloy and silicone rubber were made as contraceptive devices. The frame of the oviduct plug is made of silicone rubber and Ni-Ti shape memory alloy wire. The central part of the frame resembles a circular cylinder and the amphi-terminal of the frame is like a spigot which is formed with three mounting rings. Thirty-five New Zealand adult female rabbits were randomly divided into three groups. Thirty rabbits in Group 1 were used to test the contraceptive effect of the oviduct plug. Ten rabbits in Group 2 were used to assess the reproductive reversibility of the rabbits; 3 months after the operation, the oviduct plugs were removed from the junction of the uterus and tubes by incision of the abdomen. Another five rabbits (Group 3) served as the control group. In 30 female rabbits (Group 1), the plugs were inserted into the oviducts via a 0.5-cm incision of the uterus by using an inserter that contained the plug, then the female rabbits copulated with male rabbits once a week after the operation for 1 month. The plugs were then taken out from 10 rabbits (Group 2) 3 months after the operation.

RESULTS

Out of 30 cases (Group 1), only one rabbit from Group 1 was pregnant 2 months after the insertion of the plugs due to improper insertion. However, five rabbits in the control group were all pregnant. All 10 rabbits from Group 2 were pregnant 1 month after the plug was removed.

CONCLUSION

The oviduct plug with Ni-Ti shape memory alloy and silicone rubber is a new, effective and reversible contraceptive tool.

摘要

背景

本研究旨在观察镍钛（Ni-Ti）形状记忆合金和硅橡胶输卵管塞在兔体内的避孕效果和可逆性。

研究设计

制作镍钛形状记忆合金和硅橡胶输卵管塞作为避孕装置。输卵管塞的框架由硅橡胶和镍钛形状记忆合金丝制成。框架的中心部分呈圆柱形，框架的两端呈龙头状，由三个安装环组成。将 35 只新西兰成年雌性兔随机分为三组。第 1 组 30 只兔用于测试输卵管塞的避孕效果。第 2 组 10 只兔用于评估兔的生殖可逆性；术后 3 个月，通过腹部切口从子宫与输卵管交界处取出输卵管塞。另 5 只兔（第 3 组）作为对照组。在 30 只雌性兔（第 1 组）中，通过子宫 0.5cm 的切口将塞子插入输卵管，然后使用装有塞子的插入器进行操作，术后每周与雄性兔交配一次，持续 1 个月。术后 3 个月，从第 2 组的 10 只兔中取出塞子。