Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6-10, D-91054 Erlangen, Germany.
J Psychiatr Res. 2011 Sep;45(9):1178-83. doi: 10.1016/j.jpsychires.2011.02.006. Epub 2011 Mar 11.
The influence of repetitive transcranial magnetic stimulation (rTMS) on mood in healthy people is uncertain, as former studies show divergent results. Previous studies in healthy volunteers focused exclusively on the immediate effect of a single session of rTMS. In contrast the aim of this randomised sham-controlled study was to analyse the influence on mood of a series of 9 High Frequency (HF) rTMS stimulations of the left dorsolateral prefrontal cortex (DLPFC). 44 young healthy male volunteers were randomly assigned to receive 9 sessions of active HF-rTMS (n = 22) or sham rTMS (n = 22) over the left DLPFC. Each session in the active group consisted of 15 trains of 25 Hz starting with 100% of motor threshold. Sham stimulation was performed following the same protocol, but using a sham coil. The variables of interest were the Beck Depression Inventory (BDI) and six Visual Analogue Scales (VAS) which quantified "mood", "enjoyment" and "energy". We found a significant reduction of the BDI sum score in the active group (GLM, p < 0.001) whereas no significant changes of the BDI sum score were caused by sham stimulation (GLM, p = 0.109). The BDI single item analyses revealed within and between group differences supporting the modifying effect of rTMS on BDI. According to the employed VAS we did not find significant differences caused by active or sham stimulation in five of six VAS. In the VAS labelled lively/gloomy the active group was found to be more "gloomy" (p = 0.0111) immediately after stimulation. Our data show that a 9-day long series of HF-rTMS of the left DLPFC improves mood, analysed by BDI in healthy young men, whereas no significant long-term changes were found in VAS.
重复经颅磁刺激（rTMS）对健康人的情绪影响尚不确定，因为以前的研究结果存在差异。以前的研究仅专注于单次 rTMS 治疗的即时效应。相比之下，这项随机假刺激对照研究的目的是分析左背外侧前额叶皮层（DLPFC）的 9 次高频（HF）rTMS 刺激对情绪的影响。44 名年轻健康男性志愿者被随机分配接受 9 次左 DLPFC 接受活性 HF-rTMS（n=22）或假刺激 rTMS（n=22）。每个治疗组的治疗包括 15 个 25Hz 重复的刺激序列，起始强度为 100%运动阈值。假刺激按照相同的方案进行，但使用假线圈。感兴趣的变量是贝克抑郁量表（BDI）和 6 个视觉模拟量表（VAS），用于量化“情绪”、“享受”和“能量”。我们发现治疗组的 BDI 总分显著降低（GLM，p<0.001），而假刺激组的 BDI 总分无显著变化（GLM，p=0.109）。BDI 单项分析显示，rTMS 对 BDI 的影响具有组内和组间差异。根据使用的 VAS，我们没有发现 6 个 VAS 中的 5 个因活性或假刺激而产生的显著差异。在 VAS 标签为活跃/忧郁的项目中，治疗组治疗后立即表现出更“忧郁”（p=0.0111）。我们的数据表明，左 DLPFC 的 9 天高频 rTMS 系列可改善健康年轻男性的情绪，这通过 BDI 分析得出，而在 VAS 中未发现显著的长期变化。
