Mondino Marine, Thiffault François, Fecteau Shirley
Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Faculté de Médecine, Université Laval Québec City, QC, Canada.
Front Cell Neurosci. 2015 Oct 14;9:399. doi: 10.3389/fncel.2015.00399. eCollection 2015.
The dorsolateral prefrontal cortex (DLPFC) is often targeted with non-invasive brain stimulation (NIBS) to modulate in vivo human behaviors. This brain region plays a key role in mood, emotional processing, and attentional processing of emotional information. In this article, we ask the question: when we target the DLPFC with NIBS, do we modulate these processes altogether, non-specifically, or can we modulate them selectively? We thus review articles investigating the effects of NIBS applied over the DLPFC on mood, emotional processing, and attentional processing of emotional stimuli in healthy subjects. We discuss that NIBS over the DLPFC can modulate emotional processing and attentional processing of emotional stimuli, without specifically influencing mood. Indeed, there seems to be a lack of evidence that NIBS over the DLPFC influences mood in healthy individuals. Finally, there appears to be a hemispheric lateralization: when applied over the left DLPFC, NIBS improved processing of positive stimuli and reduced selective attention for stimuli expressing anger, whereas when applied over the right DLPFC, it increased selective attention for stimuli expressing anger.
背外侧前额叶皮层（DLPFC）常常是无创脑刺激（NIBS）的作用靶点，用于调节人类的体内行为。该脑区在情绪、情绪加工以及对情绪信息的注意力加工方面发挥着关键作用。在本文中，我们提出这样一个问题：当我们用NIBS作用于DLPFC时，我们是对这些过程进行整体的、非特异性的调节，还是能够进行选择性调节？因此，我们回顾了一些研究文章，这些文章探讨了在健康受试者中，将NIBS施加于DLPFC对情绪、情绪加工以及对情绪刺激的注意力加工所产生的影响。我们讨论了对DLPFC进行NIBS能够调节对情绪刺激的情绪加工和注意力加工，而不会特异性地影响情绪。的确，似乎缺乏证据表明对DLPFC进行NIBS会影响健康个体的情绪。最后，似乎存在半球侧化现象：当将NIBS施加于左侧DLPFC时，改善了对积极刺激的加工，并减少了对表达愤怒的刺激的选择性注意，而当将NIBS施加于右侧DLPFC时，则增加了对表达愤怒的刺激的选择性注意。
