Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Psychoneuroendocrinology. 2011 Sep;36(8):1148-53. doi: 10.1016/j.psyneuen.2011.02.006. Epub 2011 Mar 11.
Several recent findings indicate that various interactions between nervous and immune system are important in the pathophysiology of alexithymia. These findings show that a significant role in developing alexithymia may play proinflammatory cytokines. Recent data also indicate that negative emotions related to depressive symptoms and anxiety are related to disturbed levels of interleukin-8 (IL-8). These findings suggest that IL-8 could present also useful immunological marker related to emotional dysregulation in alexithymia. In the present study we have performed psychometric measurement of alexithymia (TAS-20), depression (BDI-II) and anxiety (SAS), and immunochemical measure of cerebrospinal fluid (CSF) and serum levels of IL-8 in 33 inpatients with non-inflammatory neurological disorders (NIND) (mean age 38.8±12.5). The results show that IL-8 in CSF is significantly correlated with TAS-20 (Spearman R=0.46, p=0.007) and SAS (Spearman R=0.44, p=0.009) but not to BDI-II. The findings of the present study indicate that increased level of IL-8 (in CSF) may be related to symptoms of alexithymia and anxiety in patients with NIND.
几项最近的研究结果表明，神经系统和免疫系统之间的各种相互作用在述情障碍的病理生理学中很重要。这些研究结果表明，促炎细胞因子在述情障碍的发展中可能起着重要作用。最近的数据还表明，与抑郁症状和焦虑相关的负性情绪与白细胞介素-8（IL-8）水平的紊乱有关。这些研究结果表明，IL-8 也可能是与述情障碍中情绪失调相关的有用免疫标志物。在本研究中，我们对 33 名非炎症性神经疾病（NIND）患者（平均年龄 38.8±12.5）进行了述情障碍（TAS-20）、抑郁（BDI-II）和焦虑（SAS）的心理测量，以及脑脊液（CSF）和血清中白细胞介素-8（IL-8）的免疫化学测量。结果表明，CSF 中的 IL-8 与 TAS-20（Spearman R=0.46，p=0.007）和 SAS（Spearman R=0.44，p=0.009）显著相关，但与 BDI-II 无关。本研究的结果表明，NIND 患者 CSF 中 IL-8 水平升高可能与述情障碍和焦虑症状有关。
