Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry & UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Neurosci Lett. 2012 Nov 7;529(2):139-43. doi: 10.1016/j.neulet.2012.09.003. Epub 2012 Sep 13.
Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II), anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p<0.0009) but not with SAS and TAS-20. The finding indicates that decreased level of S100B in CSF is related to increased symptoms of depression in the NIND patients.
最近的研究结果表明，神经元和神经胶质系统之间存在着许多相互作用，这些相互作用可能在抑郁症的病理生理学中发挥作用。这些发现表明，胶质衍生的神经营养蛋白 S100B 可能在抑郁症的发展中发挥重要作用。为了检验 S100B 与抑郁症状之间的关系，我们设计了一项横断面临床研究，包括非炎症性疾病（NIND）神经科患者的血清和脑脊液 S100B 水平，这些患者因诊断目的进行了脑脊液评估。本研究集中于对 40 名 NIND 住院患者的抑郁（BDI-II）、焦虑（SAS）和述情障碍（TAS-20）进行心理测试，以及对脑脊液（CSF）和血清 S100B 的神经化学测量。主要结果表明，CSF 中的 S100B 与 BDI-II 呈显著负相关（Spearman R=-0.51，p<0.0009），但与 SAS 和 TAS-20 不相关。这一发现表明，NIND 患者脑脊液中 S100B 水平降低与抑郁症状加重有关。
