芽殖酵母中新鉴定的朊病毒及其可能的功能。
Newly identified prions in budding yeast, and their possible functions.
机构信息
Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Chicago, IL 60611, USA.
出版信息
Semin Cell Dev Biol. 2011 Jul;22(5):452-9. doi: 10.1016/j.semcdb.2011.03.003. Epub 2011 Mar 21.
Abstract
Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR+], [MOT3+], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology.
摘要
酵母朊病毒是一种非典型的遗传因子，以可遗传的蛋白质构象形式进行传递。[PSI+]、[URE3]和[PIN+]是芽殖酵母酿酒酵母中研究得最为透彻的三种朊病毒。在过去的三年中，酵母中又报道了几种其他的朊病毒，包括[SWI+]、[OCT+]、[MCA]、[GAR+]、[MOT3+]、[ISP+]和[NSI+]。酵母朊病毒数量的不断增加表明，基于蛋白质的遗传可能是一种广泛存在的生物学现象。在这篇综述中，我们总结了每个朊病毒元件的特征，并讨论了它们在酵母生物学中的潜在功能作用。
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