Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80525, USA.
Dev Cell. 2011 Mar 15;20(3):283-4. doi: 10.1016/j.devcel.2011.03.001.
Formins are well-known for promoting actin assembly, but they also play a lesser-studied role in microtubule stabilization. In this issue of Developmental Cell, Cheng et al. (2011) demonstrate that the formin homology protein mDia3 is regulated by Aurora B Kinase and contributes to the generation of kinetochore-microtubule attachments in mitosis.
formin 家族以促进肌动蛋白组装而闻名,但它们在微管稳定中也发挥着研究较少的作用。在本期《发育细胞》中,Cheng 等人(2011)表明,formin 同源蛋白 mDia3 受 Aurora B 激酶调控,并有助于有丝分裂中动粒-微管附着的产生。