piRNAs 遇见线粒体。
piRNAs meet mitochondria.
机构信息
California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
出版信息
Dev Cell. 2011 Mar 15;20(3):287-8. doi: 10.1016/j.devcel.2011.03.003.
PMID:21397839
Abstract
zuc/MitoPLD encodes a conserved enzyme that localizes to mitochondria and hydrolyzes the mitochondria-specific lipid cardiolipin. Surprisingly, zuc/MitoPLD activity is required for Piwi-interacting RNA (piRNA)-mediated silencing of transposable elements in fly and mouse germlines, suggesting that signaling from mitochondria influences the piRNA pathway.
摘要
zuc/MitoPLD 编码一种保守的酶，该酶定位于线粒体并水解线粒体特异性脂质心磷脂。令人惊讶的是，zuc/MitoPLD 活性对于果蝇和小鼠生殖细胞中线粒体衍生的 Piwi 相互作用 RNA (piRNA)介导的转座元件沉默是必需的，这表明线粒体信号影响 piRNA 途径。
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