通过 ROS 逃避细胞凋亡：ANGPTL4 通过 Nox1 控制整合素信号。
Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1.
机构信息
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Cancer Cell. 2011 Mar 8;19(3):297-9. doi: 10.1016/j.ccr.2011.02.019.
PMID:21397852
Abstract
Reactive oxygen species (ROS) mediate various cell fate decisions in normal and transformed cells. In this issue of Cancer Cell, Zhu et al. demonstrate the ability of ANGPTL4 to engage integrin-dependent survival signals by activation of the NADPH oxidase Nox1, thus mimicking anchorage conditions and bypassing anoikis by controlling ROS.
摘要
活性氧（ROS）在正常细胞和转化细胞中调节各种细胞命运决定。在本期《癌细胞》杂志中，Zhu 等人证明了 ANGPTL4 通过激活 NADPH 氧化酶 Nox1 来参与整合素依赖的存活信号，从而通过控制 ROS 模拟锚定条件并绕过失巢凋亡。
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