Department of Clinical Neurosciences, San Raffaele Scientific Institute and University Vita-Salute, Milan, Italy.
J Affect Disord. 2011 Jul;132(1-2):297-300. doi: 10.1016/j.jad.2011.02.024. Epub 2011 Mar 12.
In animals, a higher density of 5-HT1A receptors has been associated with increased behavioral despair after stress. In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide.
We studied the association of rs6295 with the amount of stress in early life and preceding hospitalization for a major depressive episode in course of bipolar disorder.
In 74 consecutively admitted inpatients, early life and recent stressors were rated on the Social Readjustment Rating Scale and on the Risky Family Questionnaire.
Homozygote carriers of the rs6295 G variant reported less stressful events before current hospitalization for bipolar depression, but not in early life. The G variant was also associated with a higher overall medication load in naturalistic settings before hospitalization.
This is the first study that associated 5-HT1A receptor promoter gene variants with stressors preceding the need of hospitalization for bipolar depression. Our findings support the hypothesis that genetic factors affecting serotonergic neurotransmission might contribute to shape the individual resilience to the depressogenic effects of stress in clinical settings.
在动物中，5-HT1A 受体的密度较高与应激后行为绝望增加有关。在人类中，5-HT1A 受体启动子基因 C(-1019)G 多态性（rs6295）的 G 变体与 5-HT1A 受体表达增加、抑郁加重和自杀前压力降低有关。
我们研究了 rs6295 与双相障碍发病过程中重度抑郁症住院前的早期生活和近期压力的关系。
在 74 名连续入院的患者中，使用社会再适应评定量表和危险家庭问卷对早期生活和近期压力源进行评分。
rs6295 G 变体纯合子携带者在当前住院治疗双相抑郁症之前报告的压力事件较少，但在早期生活中则不然。G 变体还与住院前自然环境中整体药物负荷增加有关。
这是第一项将 5-HT1A 受体启动子基因变异与双相抑郁症住院前的压力源相关联的研究。我们的研究结果支持这样一种假设，即影响 5-羟色胺能神经传递的遗传因素可能有助于在临床环境中塑造个体对压力致抑郁作用的弹性。
