National University of Singapore, Department of Medicine, Singapore.
Med Hypotheses. 2011 Jun;76(6):861-2. doi: 10.1016/j.mehy.2011.02.037. Epub 2011 Mar 12.
Dengue infection causes a significant economic, social and medical burden in affected populations in over 100 countries in the tropics and sub-tropics. Current dengue control efforts have generally focused on vector control but have not shown major impact. School-aged children are especially vulnerable to infection, due to sustained human-vector-human transmission in the close proximity environments of schools. Infection in children has a higher rate of complications, including dengue hemorrhagic fever and shock syndromes, than infections in adults. There is an urgent need for integrated and complementary population-based strategies to protect vulnerable children. We hypothesize that insecticide-treated school uniforms will reduce the incidence of dengue in school-aged children. The hypothesis would need to be tested in a community based randomized trial. If proven to be true, insecticide-treated school uniforms would be a cost-effective and scalable community based strategy to reduce the burden of dengue in children.
登革热感染在 100 多个热带和亚热带国家的受影响人群中造成了巨大的经济、社会和医疗负担。目前的登革热控制工作主要集中在病媒控制上，但并没有产生重大影响。学龄儿童由于在学校附近的近距离环境中持续发生人-媒介-人传播，因此特别容易感染。与成年人感染相比，儿童感染的并发症发生率更高，包括登革出血热和休克综合征。急需采取综合和互补的基于人群的策略来保护弱势儿童。我们假设，经杀虫剂处理的校服将降低学龄儿童登革热的发病率。这一假设需要在社区为基础的随机试验中进行检验。如果被证明是正确的，那么经杀虫剂处理的校服将是一种具有成本效益且可扩展的社区为基础的策略，可以减轻儿童登革热的负担。
