Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden.
Glob Health Action. 2012;5. doi: 10.3402/gha.v5i0.17273. Epub 2012 Mar 22.
Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme with the title of 'Comprehensive control of Dengue fever under changing climatic conditions'. Fourteen partners from several countries in Europe, Asia, and South America formed a consortium named 'DengueTools' to respond to the call to achieve better diagnosis, surveillance, prevention, and predictive models and improve our understanding of the spread of dengue to previously uninfected regions (including Europe) in the context of globalization and climate change.The consortium comprises 12 work packages to address a set of research questions in three areas:Research area 1: Develop a comprehensive early warning and surveillance system that has predictive capability for epidemic dengue and benefits from novel tools for laboratory diagnosis and vector monitoring.Research area 2: Develop novel strategies to prevent dengue in children.Research area 3: Understand and predict the risk of global spread of dengue, in particular the risk of introduction and establishment in Europe, within the context of parameters of vectorial capacity, global mobility, and climate change.In this paper, we report on the rationale and specific study objectives of 'DengueTools'. DengueTools is funded under the Health theme of the Seventh Framework Programme of the European Community, Grant Agreement Number: 282589 Dengue Tools.
登革热是一种由蚊子传播的病毒性疾病，据估计，每年在全球造成约 2.3 亿例感染，其中 2.5 万人死亡。近几十年来，随着全球约 36 亿人，即世界人口的一半以上，面临风险，特别是在热带和亚热带地区的城市中心，这种疾病的发病率和地理范围迅速上升。人口和社会变化，特别是城市化、全球化和国际旅行增加，是发病率上升和登革热感染地理扩张的主要原因。主要的研究差距继续阻碍登革热的控制。欧盟委员会在第七个框架计划下发起了一项名为“在不断变化的气候条件下全面控制登革热”的呼吁。来自欧洲、亚洲和南美洲的十四个合作伙伴组成了一个名为“DengueTools”的联盟，以响应这一号召，旨在实现更好的诊断、监测、预防和预测模型，并提高我们对全球化和气候变化背景下登革热传播到以前未受感染地区（包括欧洲）的理解。该联盟包括 12 个工作包，旨在解决三个领域的一系列研究问题：
研究领域 1：开发具有预测能力的综合预警和监测系统，利用实验室诊断和媒介监测的新工具。
研究领域 2：开发预防儿童登革热的新策略。
研究领域 3：在媒介能力、全球流动性和气候变化等参数的背景下，了解和预测登革热的全球传播风险，特别是在欧洲的传入和建立风险。
在本文中，我们报告了“登革热工具”的基本原理和具体研究目标。登革热工具是根据欧盟第七个框架计划的健康主题资助的，协议号为：282589 登革热工具。
