Zanasi A, Tumietto F, Costigliola P, Ricchi E, Cacaci C, Cappelletti O, De Bernardi M
Istituto di Fiopatologia Respiratoria, Università degli Studi di Bologna.
Clin Ter. 1990 Mar 15;132(5):321-8.
The authors evaluated the effect of an orally administered polymicrobial vaccine in a group of chronic bronchitis patients in order to assess its efficacy in preventing recurrent infections and as adjuvants during minor acute episodes. Compared to the control group, vaccinated patients had 1) a reduced number of flare-ups, and these were less severe and symptoms were improved; II) lymphocyte phenotype was not altered in any of the patients but nevertheless the response to skin tests for delayed sensitivity was improved in the vaccinated patients only; III) more rapid symptomatic improvement of flare-ups. The authors stress the improvement of cell-mediated lymphocyte function as a result of vaccination, probably due to macrophage activation and with resulting improvement of the clinical course of the bronchial disorder.
作者评估了口服多微生物疫苗对一组慢性支气管炎患者的影响，以评估其在预防反复感染以及作为轻度急性发作期辅助药物方面的疗效。与对照组相比，接种疫苗的患者有：1）发作次数减少，且发作程度较轻，症状有所改善；二）所有患者的淋巴细胞表型均未改变，但仅接种疫苗的患者对迟发型超敏反应的皮肤试验反应有所改善；三）发作症状改善更快。作者强调，接种疫苗可改善细胞介导的淋巴细胞功能，这可能是由于巨噬细胞活化，从而改善了支气管疾病的临床病程。
