Tandon M K, Gebski V
Thoracic Division, Repatriation General Hospital, Perth, WA.
Aust N Z J Med. 1991 Aug;21(4):427-32. doi: 10.1111/j.1445-5994.1991.tb01346.x.
Sixty-four patients with chronic bronchitis with a history of recurrent respiratory tract infections were admitted to a double-blind randomised controlled study in which the efficacy of an oral vaccine containing killed Haemophilus influenzae in preventing acute exacerbations of chronic bronchitis was compared with placebo. Patients given vaccine developed fewer acute infective episodes. Although the numbers of patients who required antibiotic therapy in the two groups were not significantly different, the number of antibiotic prescriptions given to the vaccinated group of patients was significantly less than that required by the control group. A reduction in colonisation with Haemophilus influenzae occurred in the active group, which was maximal 14 weeks after the onset of the study.
64例有反复呼吸道感染病史的慢性支气管炎患者被纳入一项双盲随机对照研究，该研究比较了一种含灭活流感嗜血杆菌的口服疫苗预防慢性支气管炎急性加重的疗效与安慰剂的疗效。接种疫苗的患者发生的急性感染发作较少。虽然两组中需要抗生素治疗的患者人数无显著差异，但接种疫苗组患者的抗生素处方数量明显少于对照组。活性组中流感嗜血杆菌的定植有所减少，在研究开始后14周时降至最低。
