Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215-1204, USA.
Cephalalgia. 2011 May;31(7):861-9. doi: 10.1177/0333102411401635. Epub 2011 Mar 11.
Migraine has a wide clinical spectrum. Our aim was to group information on migraine characteristics into meaningful components and to identify key components of the migraine phenotype.
We performed two principal component analyses, one among participants in the Women's Health Study enrollment cohort and one in a sub-cohort with additional migraine-specific information.
Among the 9427 women with migraine attack-related information at enrollment, the three most important components pertained to central nervous system (CNS) sensitization, attack frequency/pain location and aura/visual phenomena. In the subgroup of 1675 women with more detailed information, food triggers and unspecific symptoms constituted two principal components that explain more of the variance of the migraine phenotype than the three attack-related components.
Our results indicate that information on migraine-associated features, symptoms and triggers is highly correlated, allowing the extraction of principal components. Migraine attack-related symptoms are best summarized by symptoms related to CNS sensitization, attack frequency/pain location and aura/visual phenomena. Taking a more general view, unspecific symptoms and food triggers appear to carry stronger importance in characterizing the migraine phenotype. These components are useful for future research on the pathophysiology and genetics of migraine and may have implications for diagnosing and treating patients.
偏头痛具有广泛的临床谱。我们的目的是将偏头痛特征的信息分组为有意义的成分，并确定偏头痛表型的关键成分。
我们进行了两次主成分分析，一次是在妇女健康研究入组队列的参与者中进行的，另一次是在具有额外偏头痛特异性信息的亚队列中进行的。
在入组时具有偏头痛发作相关信息的 9427 名女性中，与中枢神经系统（CNS）敏化、发作频率/疼痛部位和先兆/视觉现象相关的三个最重要的成分。在有更详细信息的 1675 名女性亚组中，食物触发和非特异性症状构成了两个主要成分，比与发作相关的三个成分更能解释偏头痛表型的更多变异。
我们的结果表明，与偏头痛相关的特征、症状和诱因的信息高度相关，允许提取主要成分。与 CNS 敏化、发作频率/疼痛部位和先兆/视觉现象相关的症状最好概括偏头痛发作相关症状。从更广泛的角度来看，非特异性症状和食物触发似乎在表征偏头痛表型方面更为重要。这些成分对于偏头痛的病理生理学和遗传学的未来研究很有用，并且可能对诊断和治疗患者具有意义。
