Kohnert K D, Fält K, Ziegler B, Odselius R, Ziegler M, Falkmer S
Central Institute of Diabetes, Gerhardt Katsch, Karlsburg/GDR.
Exp Clin Endocrinol. 1990 Feb;95(1):47-56. doi: 10.1055/s-0029-1210933.
Neither injection of complete Freund's adjuvant (CFA) alone nor the administration of low doses of streptozotocin (STZ) to rats produced remarkable histopathological changes in the endocrine pancreas, but treatment with the combination of both resulted in necrosis of beta cells. When the combination of CFA/STZ was given two times, necrosis progressed, and the beta cell reserve was depleted to such an extend that persistent hyperglycemia ensued. These changes were associated with a significant reduction in the apparent islet size. A single injection of CFA induced pancreatitis and inflammatory lesions in the exocrine parenchyma with no insular involvement. Three injections caused extensive destruction of pancreatic acinar tissue but only moderate beta cell injury in the minority of islets. Apart from mild degranulation of beta cells, treatment with STZ did not produce histopathological changes in the pancreas. These results suggest that the acute inflammatory process induced by CFA may initially damage the beta cells, increasing thereby their susceptibility to the action of STZ.
单独给大鼠注射完全弗氏佐剂（CFA）或给予低剂量链脲佐菌素（STZ）均未在内分泌胰腺中产生明显的组织病理学变化，但两者联合处理会导致β细胞坏死。当给予两次CFA/STZ联合处理时，坏死进展，β细胞储备耗竭到如此程度，以至于随后出现持续性高血糖。这些变化与胰岛明显变小有关。单次注射CFA可诱发外分泌实质的胰腺炎和炎性病变，不累及胰岛。三次注射导致胰腺腺泡组织广泛破坏，但仅少数胰岛中的β细胞受到中度损伤。除了β细胞轻度脱颗粒外，STZ处理未在胰腺中产生组织病理学变化。这些结果表明，CFA诱导的急性炎症过程可能最初会损伤β细胞，从而增加其对STZ作用的敏感性。
