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链霉菌中 RNA 聚合酶抑制剂链雷菌素的生物合成：3-甲基天冬氨酸的修饰改造。

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

机构信息

Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.

出版信息

J Bacteriol. 2011 May;193(10):2647-51. doi: 10.1128/JB.00108-11. Epub 2011 Mar 11.

DOI:10.1128/JB.00108-11
PMID:21398531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3133142/
Abstract

The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production.

摘要

天冬氨酰-tRNA 合成酶样 SlgZ 和甲基转移酶 SlgM 酶参与利迪链丝菌中天冬氨酰四酸streptolydigin 的生物合成。SlgZ 的失活导致了一种新型的streptolydigin 衍生物。在利迪链丝菌中过表达 slgZ、slgM 或两者都导致 streptolydigin 产量的显著增加。

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3
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4
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Nat Chem Biol. 2009 Jun;5(6):414-20. doi: 10.1038/nchembio.175.
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6
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