两株金黄色葡萄球菌绵羊分离株的基因组序列，可引起严重（菌株 O11）和轻度（菌株 O46）乳腺炎。
Genome sequences of two Staphylococcus aureus ovine strains that induce severe (strain O11) and mild (strain O46) mastitis.
机构信息
INRA, UMR1253 Science et Technologie du Lait et de l'Œuf, F-35042 Rennes, France.
出版信息
J Bacteriol. 2011 May;193(9):2353-4. doi: 10.1128/JB.00045-11. Epub 2011 Mar 11.
Abstract
Staphylococcus aureus is a major etiological agent of mastitis in ruminants. We report here the genome sequences of two ovine strains that were isolated from gangrenous (strain O11) and subclinical (strain O46) ewe mastitis. Both strains belong to the same clonal complex. Despite this close genotypic relationship, the two isolates were shown to reproducibly induce highly divergent types of infections, either severe (O11) or mild (O46) mastitis, in an experimental ewe model.
摘要
金黄色葡萄球菌是反刍动物乳腺炎的主要病因。我们在此报告了从坏疽性（O11 株）和亚临床性（O46 株）绵羊乳腺炎中分离出的两株绵羊分离株的基因组序列。两株菌均属于同一克隆复合体。尽管存在这种密切的遗传关系，但这两个分离株在绵羊实验模型中被证明能够重复地引起高度不同类型的感染，要么是严重（O11），要么是轻度（O46）乳腺炎。
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