促性腺激素与肾上腺雄激素分泌的独立性。

Independence of gonadotropin and adrenal androgen secretion.

作者信息

Lee P A, Xenakis T, Winer J, Matsenbaugh S

出版信息

Andrologia. 1978 Sep-Oct;10(5):369-72. doi: 10.1111/j.1439-0272.1978.tb03050.x.

DOI:10.1111/j.1439-0272.1978.tb03050.x

Abstract

Five groups of 5 normal adult males have been studied. Group 1 received clomiphene, group 2 received exogenous FSH and group 3 testosterone. These three groups received drugs to stimulate LH and FSH, increase levels of FSH or suppress LH and FSH respectively. Circulating levels of testosterone (T), estrone (E1) and 17-hydroxyprogesterone (17-OHP) were altered while serum concentrations of androstenedione (A), dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DS) and urinary 17-ketosteroids (17-KS) were not. The other two groups of 5 adult males had adrenal androgen levels suppressed or stimulated while receiving dexamethasone or ACTH. Serum 17 OHP, A, DHA and DS levels and urinary 17 KS were affected while gonadotropins were unaltered. Hence, no relationship has been demonstrated between circulating levels of adrenal androgens and gonadotropins.

摘要

对五组每组5名正常成年男性进行了研究。第1组接受克罗米芬，第2组接受外源性促卵泡激素（FSH），第3组接受睾酮。这三组分别接受药物以刺激促黄体生成素（LH）和FSH、提高FSH水平或抑制LH和FSH。睾酮（T）、雌酮（E1）和17-羟孕酮（17-OHP）的循环水平发生了改变，而雄烯二酮（A）、脱氢表雄酮（DHA）、硫酸脱氢表雄酮（DS）的血清浓度和尿17-酮类固醇（17-KS）则未改变。另外两组每组5名成年男性在接受地塞米松或促肾上腺皮质激素（ACTH）时，肾上腺雄激素水平受到抑制或刺激。血清17-OHP、A、DHA和DS水平以及尿17-KS受到影响，而促性腺激素未改变。因此，尚未证明肾上腺雄激素的循环水平与促性腺激素之间存在关联。