Lee P A, Kowarski A, Migeon C J, Blizzard R M
J Clin Endocrinol Metab. 1975 Apr;40(4):664-9. doi: 10.1210/jcem-40-4-664.
To evaluate the relationship between the secretion of gonadotropins and adrenal androgens, patients with gonadal agenesis were evaluated by (a) administering human luteinizing hormone (hLH) for 5 days with or without estrogen pretreatment to agonadal patients who had prepubertal LH levels; (b) correlating circulating gonadotropin levels with adrenal androgens in 45 patients; and (c) comparing adrenal androgens with gonadotropins after long-term administration of estrogen or androgens. Results are as follows: (a) No alteration in serum concentrations of dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), estrone (E1), testosterone (T), or in excretion of urinary 17-ketosteroid (17 KS) occurred after the administration of hLH. (b) No clearcut relationship between endogenous level of LH or FSH and DHA OR DHAS was demonstrated although a coincident increase of all hormones with age occurred. (c) Administration of estrogen to patients with gonadal agenesis did not affect their levels of DHA and DHAS although those patients given androgen developed higher DHAS, but not DHA, levels. Hence, increasing gonadotropin concentrations would not appear to be a primary etiologic factor in the maturation of the adrenal.
为评估促性腺激素分泌与肾上腺雄激素之间的关系，对性腺发育不全患者进行了以下评估：(a) 对青春期前促黄体生成素（LH）水平的性腺发育不全患者，给予人促黄体生成素（hLH）5天，同时进行或不进行雌激素预处理；(b) 对45例患者的循环促性腺激素水平与肾上腺雄激素进行相关性分析；(c) 长期给予雌激素或雄激素后，比较肾上腺雄激素与促性腺激素水平。结果如下：(a) 给予hLH后，血清脱氢表雄酮（DHA）、硫酸脱氢表雄酮（DHAS）、雌酮（E1）、睾酮（T）浓度及尿17-酮类固醇（17 KS）排泄均无变化。(b) 虽然所有激素水平均随年龄同步升高，但未显示内源性LH或FSH水平与DHA或DHAS之间存在明确关系。(c) 对性腺发育不全患者给予雌激素不影响其DHA和DHAS水平，而给予雄激素的患者DHAS水平升高，但DHA水平未升高。因此，促性腺激素浓度升高似乎不是肾上腺成熟的主要病因。
