Southern Urals Biophysics Institute, Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, 456780 Russian Federation.
Health Phys. 2011 Feb;100(2):176-84. doi: 10.1097/HP.0b013e3181ebd123.
Findings from the analyses of the dose-response relationship are reviewed with regard to different effects of acute radiation exposure. The analyses have been performed based on the dosimetry and clinical data for the nuclear workers acutely exposed to gamma rays or gamma rays and neutrons as a result of radiation accidents at the Mayak Production Association (Russia). The statistically significant risk curves for morbidity and mortality from acute radiation syndrome (ARS), as well as risks of the onset of vomiting at the prodromal phase and agranulocytosis, have been obtained. The Weibull model appropriately describes the corresponding risk curves. Estimates of the dose thresholds have been obtained for ARS morbidity (∼0.7 Gy) and mortality (∼6-7 Gy), vomiting at the prodromal phase (∼1.5 Gy), and agranulocytosis (∼3.5 Gy). The statistically significant power dependence between the onset of vomiting at the prodromal phase and the onset of agranulocytosis, as well as the dose dependence for the onset of agranulocytosis, has been revealed.
针对不同的急性辐射暴露效应，对剂量-反应关系的分析结果进行了回顾。这些分析是基于俄罗斯马雅克生产协会（Mayak Production Association）辐射事故中γ射线或γ射线和中子急性暴露的核工作人员的剂量测定和临床数据进行的。获得了急性辐射综合征（ARS）发病率和死亡率以及前驱期呕吐和粒细胞缺乏症发病风险的统计学显著风险曲线。威布尔模型适当地描述了相应的风险曲线。获得了 ARS 发病率（约 0.7 Gy）和死亡率（约 6-7 Gy）、前驱期呕吐（约 1.5 Gy）和粒细胞缺乏症（约 3.5 Gy）的剂量阈值估计。揭示了前驱期呕吐和粒细胞缺乏症发病之间以及粒细胞缺乏症发病的剂量依赖性的统计学显著幂律依赖性。
