Macià I Garau Miquel, Lucas Calduch Anna, López Enric Casanovas
Radiation Oncology Department, Institut Català d'Oncologia, Hospital Duran i Reynals, Avda Granvía de l'Hospitalet, 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
Radiation Oncology Department, Institut Català d'Oncologia, Hospital Duran i Reynals, 08907 L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
Rep Pract Oncol Radiother. 2011 Jul 6;16(4):123-30. doi: 10.1016/j.rpor.2011.06.001.
the hematopoietic, gastrointestinal and neurovascular syndrome but many other tissues can be damaged. The time course and severity of clinical signs and symptoms are a function of the overall body volume irradiated, the inhomogeneity of dose exposure, the particle type, the absorbed dose and the dose rate. Classical pathophysiology explain the failure of each of these organs and the timing of appearance of their signs and symptoms due to radiation-induced cytocidal effects of a great number of parenchymal cells of hierarchically organized tissues. Contemporaneously, many other radiation-induced effects has been described and all of them may lead to tissue injury with their corresponding signs and symptoms that can be expressed after short or long period of time. Radiation-induced multi-organ involvement is thought to be due to radiation-induced systemic inflammatory response mediated by released pro-inflammatory cytokines.
造血综合征、胃肠综合征和神经血管综合征，但许多其他组织也可能受损。临床体征和症状的时间进程及严重程度取决于受照射的全身体积、剂量暴露的不均匀性、粒子类型、吸收剂量和剂量率。经典的病理生理学解释了这些器官各自的功能衰竭以及由于辐射对分层组织中大量实质细胞产生的杀细胞效应而出现其体征和症状的时间。同时，还描述了许多其他辐射诱导效应，所有这些效应都可能导致组织损伤，并伴有在短时间或长时间后可能出现的相应体征和症状。辐射诱导的多器官受累被认为是由释放的促炎细胞因子介导的辐射诱导全身炎症反应所致。
