晚期糖基化终产物受体与磷脂酰丝氨酸结合，并协助清除凋亡细胞。
Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells.
机构信息
Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
出版信息
EMBO Rep. 2011 Apr;12(4):358-64. doi: 10.1038/embor.2011.28. Epub 2011 Mar 11.
Abstract
Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an 'eat-me' signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage(-/-)) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage(-/-) mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.
摘要
细胞凋亡的清除对于组织发育、内稳态和炎症的消退是必要的。凋亡细胞的摄取是由细胞表面的“吃我”信号（如磷脂酰丝氨酸）引发的，吞噬细胞通过使用特定的受体来识别信号。在这项研究中，我们表明，晚期糖基化终产物（RAGE）受体的可溶性形式与磷脂酰丝氨酸以及凋亡的胸腺细胞结合。RAGE 缺陷型（Rage(-/-)）肺泡巨噬细胞显示出对凋亡的胸腺细胞的吞噬作用受损，并且在 Rage(-/-)小鼠中对凋亡的中性粒细胞的清除作用有缺陷。我们的结果表明，RAGE 作为磷脂酰丝氨酸受体发挥作用，并有助于清除凋亡细胞。
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