Park Walter G
Division of Gastroenterology & Hepatology, Department of Medicine, Stanford University School of Medicine 300 Pasteur Drive, H0262, MC: 5244, Stanford, CA, 94305 USA.
F1000 Med Rep. 2011 Feb 1;3:3. doi: 10.3410/M3-3.
Pancreatic cysts are increasingly recognized as a dilemma in clinical practice because of their uncertain risk of malignancy. Because diagnosis by cytology is insensitive, current guidelines suggest using radiographic and clinical criteria to determine the appropriateness of surgery or surveillance, although this is far from perfect. Several cyst fluid biomarkers have been reported to aid diagnosis, and to date, carcinoembryonic antigen is the most accurate in detecting potentially cancerous mucinous cysts, but not in detecting malignant cysts. Recent studies have highlighted novel cyst fluid biomarkers based on DNA analysis, protein expression profiling, and secreted proteins that, if validated, may improve diagnosis and management.
胰腺囊肿在临床实践中日益被视为一个难题，因为其恶变风险不确定。由于细胞学诊断不敏感，目前的指南建议使用影像学和临床标准来确定手术或监测的适宜性，尽管这远非完美。已有几种囊液生物标志物被报道有助于诊断，迄今为止，癌胚抗原在检测潜在癌性黏液性囊肿方面最为准确，但在检测恶性囊肿方面并不准确。最近的研究突出了基于DNA分析、蛋白质表达谱和分泌蛋白的新型囊液生物标志物，若能得到验证，可能会改善诊断和管理。
