Kwon Richard S, Simeone Diane M
Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, Taubman 3912, Ann Arbor, MI 48109-5362, USA.
Int J Proteomics. 2011;2011:413646. doi: 10.1155/2011/413646. Epub 2011 Oct 24.
Proteomics is a powerful method used to identify, characterize, and quantify proteins within biologic samples. Pancreatic cystic neoplasms are a common clinical entity and represent a diagnostic and management challenge due to difficulties in accurately diagnosing cystic lesions with malignant potential and assessing the risk of malignant degeneration. Currently, cytology and other biomarkers in cyst fluid have had limited success in accurately distinguishing both the type of cystic neoplasm and the presence of malignancy. Emerging data suggests that the use of protein-based biomarkers may have greater utility in helping clinicians correctly diagnose the type of cyst and to identify which cystic neoplasms are malignant. Several candidate proteins have been identified within pancreatic cystic neoplasms as potential biomarkers. Future studies will be needed to validate these findings and move these biomarkers into the clinical setting.
蛋白质组学是一种用于识别、表征和定量生物样本中蛋白质的强大方法。胰腺囊性肿瘤是一种常见的临床实体，由于难以准确诊断具有恶性潜能的囊性病变并评估恶性变风险，因此在诊断和管理方面构成挑战。目前，囊液中的细胞学检查和其他生物标志物在准确区分囊性肿瘤类型和恶性肿瘤存在方面取得的成功有限。新出现的数据表明，基于蛋白质的生物标志物在帮助临床医生正确诊断囊肿类型和识别哪些囊性肿瘤是恶性方面可能具有更大的效用。在胰腺囊性肿瘤中已鉴定出几种候选蛋白作为潜在的生物标志物。未来需要进行研究以验证这些发现并将这些生物标志物应用于临床。
