一锅法硝基-Mannich/氢胺化串联反应在碱和金催化作用下直接合成 2,5-二取代吡咯
One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis.
机构信息
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Chem Commun (Camb). 2011 Apr 21;47(15):4379-81. doi: 10.1039/c1cc10751h. Epub 2011 Mar 28.
PMID:21399786
Abstract
An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(III) catalysis is reported.
摘要
本文报道了一种高效、易于操作的一锅反应级联法，用于在碱和金（III）催化的条件下，从对甲苯磺酰基保护的亚胺和 4-硝基-1-丁炔出发合成 2,5-二取代吡咯。
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