一锅法通过碱和金催化的硝基-Mannich/氨化串联反应立体选择性合成吡咯烷衍生物。
Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis.
机构信息
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Chem Commun (Camb). 2013 Apr 7;49(27):2777-9. doi: 10.1039/c3cc40729b.
PMID:23443206
Abstract
An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.
摘要
报道了一种高效的一锅硝-曼尼希/羟胺串联反应，用于合成含有三个立体中心的取代吡咯烷。在碱和金（I）催化剂的联合控制下进行反应，该串联反应以高产率和良好到优秀的非对映选择性得到吡咯烷产物。
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