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[一例伴有视网膜血管瘤样增殖的色素性视网膜炎]

[A case of retinitis pigmentosa with retinal angiomatous proliferation].

作者信息

Nagao Yuriko, Hiramoto Yusei, Takahashi Kanji

机构信息

Department of Ophthalmology, Kansai Medical University, Hirakata Hospital, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 2011 Feb;115(2):147-50.

Abstract

PURPOSE

To report a first case of retinitis pigmentosa accompanied with retinal angiomatous proliferation (RAP).

CASE

A 60-year-old woman was diagnosed with retinitis pigmentosa. Fundus examination revealed intraretinal hemorrhage and exdates with retinal edema in the subfovea region OD. Indocyanine green angiogram revealed the presence of retino-choroidal anastomosis. These findings were compatible with the lesions observed in the form of RAP in age-related macular degeneration (AMD), which is resistant to photodynamic therapy with verteporfin and anti-vascular endothelial growth factor (VEGF) therapy.

CONCLUSION

A first case of retinitis pigmentosa accompanied with RAP presented. Although few clinical cases of retinitis pigmentosa accompanied with choroidal neovascularization have been reported, this is the first report of RAP combined with retinitis pigmentosa. Further research is required to examine the mechanism associating these two conditions.

摘要

目的

报告首例伴有视网膜血管瘤样增生(RAP)的色素性视网膜炎病例。

病例

一名60岁女性被诊断为色素性视网膜炎。眼底检查发现右眼黄斑中心凹下区域视网膜内出血及渗出伴视网膜水肿。吲哚青绿血管造影显示存在视网膜 - 脉络膜吻合。这些发现与年龄相关性黄斑变性(AMD)中以RAP形式观察到的病变相符,而后者对维替泊芬光动力疗法和抗血管内皮生长因子(VEGF)疗法均耐药。

结论

呈现首例伴有RAP的色素性视网膜炎病例。尽管此前鲜有色素性视网膜炎伴有脉络膜新生血管形成的临床病例报道,但这是RAP合并色素性视网膜炎的首例报告。需要进一步研究以探讨这两种情况相关的机制。

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