Medicines for Malaria Venture, ICC, Geneva, Switzerland.
Curr Top Med Chem. 2011;11(10):1226-54. doi: 10.2174/156802611795429194.
Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet, unfortunately, apart from artemisinin combination therapies there are relatively few effective treatments for Plasmodium falciparum and only one treatment for the radical cure of Plasmodium vivax. Novel classes of antimalarial medicines are urgently needed given the long-term inevitability of resistance to current therapies and the need for drugs that are well tolerated by all. This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches being developed as a contribution towards the malaria eradication agenda.
疟疾是我们这个时代最流行和最具破坏性的传染病之一。然而，不幸的是，除了青蒿素联合疗法外，针对恶性疟原虫和间日疟原虫根治的有效治疗方法相对较少。鉴于当前疗法的耐药性不可避免且需要所有患者都能耐受的药物，迫切需要新型抗疟药物。本综述总结了迄今为止开发和注册的抗疟药物，并描述了一些正在开发的新的小分子治疗方法，为消除疟疾议程做出贡献。
