Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
Acta Ophthalmol. 2011 Aug;89(5):e466-71. doi: 10.1111/j.1755-3768.2011.02141.x. Epub 2011 Mar 15.
To investigate changes in ocular pulse amplitude (OPA) during a short-term increase in intraocular pressure (IOP) and to assess possible influences of biometrical properties of the eye, including central corneal thickness (CCT) and axial length.
In a prospective, single centre study, OPA and IOP as measured by dynamic contour tonometry (DCT) were taken before baseline- and post-OPA (delta) intravitreal injection of 0.05 ml anti-vascular endothelial growth factor agents. Analysis was performed employing linear regression with baseline- and post (delta)-OPA differences as the dependent and post-IOP as well as delta IOP as the independent variable. A multilinear regression analysis with delta OPA as the dependent variable and baseline IOP, post-IOP, CCT and axial length as independent variables was conducted.
Forty eyes of 40 patients were included. IOP and OPA increased significantly after injection (IOP mean increase ± SD: 17.83 ± 9.83 mmHg, p < 0.001; OPA mean increase ± SD: 1.39 ± 1.16 mmHg, p < 0.001). For every mmHg increase in IOP, the OPA showed a linear increase of 0.05 mmHg (slope 0.05, 95% CI: 0.02-0.09, p = 0.003, r(2) = 0.20). Multiple regression analysis with delta OPA as the dependent variable revealed a partial correlation coefficient of 0.47 (p = 0.003) for post-IOP as the only significant contribution.
A clear positive relationship between OPA measurements and IOP levels was shown in a clinical routine setting using DCT focusing on baseline and postinterventional comparisons of OPA values after intravitreal injections in patients with exudative age related macular degeneration. When considering the OPA for diagnostic purposes, we recommend indication of corresponding IOP values.
研究眼内压（IOP）短期升高期间眼脉冲幅度（OPA）的变化，并评估眼部生物测量特性，包括中央角膜厚度（CCT）和眼轴长度，对 OPA 的可能影响。
在一项前瞻性、单中心研究中，使用动态轮廓眼压计（DCT）在基线和玻璃体内注射 0.05ml 抗血管内皮生长因子药物后的 OPA 和 IOP （delta）之前进行测量。分析采用线性回归，将基线和（delta）OPA 差异作为因变量，将 post-IOP 和 delta IOP 作为自变量。采用多元线性回归分析，将 delta OPA 作为因变量，将基线 IOP、post-IOP、CCT 和眼轴长度作为自变量。
共纳入 40 例（40 只眼）患者。注射后 IOP 和 OPA 均显著升高（IOP 平均升高 ± SD：17.83 ± 9.83mmHg，p<0.001；OPA 平均升高 ± SD：1.39 ± 1.16mmHg，p<0.001）。IOP 每增加 1mmHg，OPA 呈线性增加 0.05mmHg（斜率 0.05，95%CI：0.02-0.09，p=0.003，r(2)=0.20）。以 delta OPA 为因变量的多元回归分析显示，post-IOP 为唯一显著贡献因素的偏相关系数为 0.47（p=0.003）。
在使用 DCT 进行临床常规设置的情况下，在患有渗出性年龄相关性黄斑变性的患者中，在玻璃体内注射后进行基线和干预后 OPA 值的比较，显示出 OPA 测量值与 IOP 水平之间存在明显的正相关关系。在考虑 OPA 用于诊断目的时，我们建议注明相应的 IOP 值。
