Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.
Curr Eye Res. 2012 Feb;37(2):115-9. doi: 10.3109/02713683.2011.626910. Epub 2011 Oct 18.
To investigate the impact of cataract surgery on the association of the ocular pulse amplitude (OPA) and intraocular pressure (IOP) with respect to the interpretation of OPA as an estimate of ocular blood flow.
Twenty-four patients with cataract were included in a clinical study. OPA was measured using dynamic contour tonometry (DCT, Pascal(®), SMT Swiss Microtechnology AG, Switzerland). IOP was measured by means of Goldmann applanation tonometry (IOP GAT) and DCT (IOP DCT). All measurements were performed before and one day after cataract surgery.
At baseline, OPA was correlated to IOP GAT (r = 0.67, P = 0.0002) and IOP DCT (r = 0.82, P < 0.0001), but not to age or axial length. Postoperative OPA was correlated to IOP GAT (r = 0.67, P = 0.0002) and IOP DCT (r = 0.65, P = 0.0004). In 17 patients, IOP GAT decreased after surgery (IOP DCT n = 14), whereas an increase was apparent in seven patients (IOP DCT n = 10). The mean absolute deviation of IOP GAT pre- to post-surgery was 4.54 mmHg ± 2.47 (range 1-10 mmHg) and 5.4 mmHg ± 3.2 (range 1.1-13.1 mmHg) for IOP DCT. The changes of OPA were significantly correlated to changes in IOP GAT (r = 0.48, P = 0.017) and IOP DCT (r = 0.60, P = 0.001). IOP GAT and IOP DCT changes were not correlated to changes in corneal thickness.
The OPA measured with the Pascal(®) device seems to be dependent on IOP changes. Particular caution should be taken in the interpretation of OPA in estimating pulsatile ocular blood flow.
研究白内障手术对眼脉压（OPA）与眼压（IOP）相关性的影响，以便更好地解读 OPA 作为眼血流估计值的意义。
本临床研究纳入了 24 例白内障患者。使用动态轮廓眼压计（DCT，Pascal(®)，SMT Swiss Microtechnology AG，瑞士）测量 OPA。通过 Goldmann 压平眼压计（IOP GAT）和 DCT（IOP DCT）测量 IOP。所有测量均在白内障手术前和术后一天进行。
在基线时，OPA 与 IOP GAT（r=0.67，P=0.0002）和 IOP DCT（r=0.82，P<0.0001）相关，但与年龄或眼轴长度无关。术后 OPA 与 IOP GAT（r=0.67，P=0.0002）和 IOP DCT（r=0.65，P=0.0004）相关。在 17 例患者中，IOP GAT 在手术后降低（IOP DCT n=14），而在 7 例患者中则明显升高（IOP DCT n=10）。IOP GAT 术前至术后的平均绝对偏差为 4.54 mmHg±2.47（范围 1-10 mmHg），IOP DCT 为 5.4 mmHg±3.2（范围 1.1-13.1 mmHg）。OPA 的变化与 IOP GAT（r=0.48，P=0.017）和 IOP DCT（r=0.60，P=0.001）的变化显著相关。IOP GAT 和 IOP DCT 的变化与角膜厚度的变化无关。
使用 Pascal(®)设备测量的 OPA 似乎依赖于 IOP 变化。在解读 OPA 估计脉动性眼血流时应特别小心。
